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中國科學院廣州生物醫藥與健康研究院華南干細胞與再生醫學研究所COSMA團隊2019年8月招聘博士后啟事

博后招聘:干細胞和重組細胞中染色質功能和結構研究方向,PiaCosma課題組,中國科學院廣州生物醫藥與健康研究院

中國科學院廣州生物醫藥與健康研究院Cosma課題組擬招聘2位積極性高,在生物醫學、生物物理學或相關學科有豐富知識經驗的科研人員。博士學歷者為佳,在細胞培養和顯微鏡學方面有經驗者為佳。優先考慮在高分辨率顯微鏡或CRISPR/Cas等方面有經驗者。成功應聘者有機會在廣州生物院工作前派往西班牙巴塞羅那CRG接受STORM顯微鏡學培訓。

條件:

本職位擬招博士后,將提供滿足在巴塞羅那或廣州生活并且具有競爭力的工資。

申請流程:

應聘者請將相關資料發送給PiaCosma教授:英文CV中請附加詳細聯系方式,自薦信及2-3份推薦信(英文,附帶聯系人方式)。請將應聘資料發送至pia.cosma@crg.eu,郵件標題注明:應聘某某崗位+本人姓名+高校人才網。

本職位應聘長期開放,應聘成功者能盡快到任為佳。

廣州生物院簡介:http://www.gibh.cas.cn/

課題組簡介:

Reprogramming and Regeneration Laboratory 

Pia Cosma’s group is an internationally recognized laboratory (http://piacosmalab.com/) and will start at GIBH in August 2018. The group has as main objective to investigate the mechanisms controlling the reprogramming of somatic cells, and to determine if this reprogramming contributes to tissue regeneration in higher vertebrates. Cosma’s group has discovered that activation of the Wnt/β-catenin signalling pathway enhances cell-fusion-mediated reprogramming of somatic cells and studied extensively the mechanism behind (Lluis et al., Cell Stem Cell 2008; Stem Cells 2010; PNAS 2011; Aulicino et al., Stem Cell Report 2014; Marucci et al. Cell Reports 2014; De Jaime-Soguero et al. Plos Genetics 2017, Frade et al. Nature Cell Biology, under revision). Cosma’s group demonstrated that regeneration of the retina, dopaminergic neurons in Parkinson’s disease and of liver after hepatectomy is possible via Wnt controlled cell-fusion-mediated reprogramming (Sanges et al., Cell Reports 2013; J. of Clinical Investigation 2016; Pesaresi et al. eBioMedicine 2018; Altarche-Xifro’ eBioMedicine 2016; Pedone et al., Cell Reports 2017).  

In addition, Cosma’s Group has a long interest in studying gene and chromatin function (Cantone et al, Cell 2009). Recently using super resolution microscopy (STORM), the group has identified a new model of chromatin fiber assembly and how the fiber changes in somatic and embryonic stem cells (Ricci et al. Cell 2015, Neguembor et al., NAR 2017).  

We are currently studying the changes in chromatin structure and organization during somatic cell reprogramming and differentiation, to determine how chromatin fibers can be rearranged to overcome epigenetic barriers to gain pluripotency.  

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來源:

http://www.gibh.cas.cn/rczp/ypxx/201809/t20180903_5062012.html

 

 

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